Welcome to Li Lab

1. Zhang W, Li Z, Qiu Y, Yu Z, Liu S, Liu X, Niu W, Xiao J, Wu Z*, Li M*: Extract from crown-of-thorns starfish promotes zebrafish caudal fin regeneration by inhibition of neutrophil migration. PeerJ 2026;14:e20863

2. Deng L, Deng T, Deng Y, Zhang T, Guo J, Wang X, Wu X, Li M*: Mosloflavone induces pancreatic alpha cells transdifferentiation into beta cells through PDX1. J Nat Med 2026;80:156-171

3. Yu Z, Zhang Y, Wang W, Wu X, Liu S, Bin Y, Li H, Cai B, Wang Z, Fang M, Qi R, Li M*, Qiu Y*: Novel araucarene diterpenes from Agathis dammara exert hypoglycemic activity by promoting pancreatic beta cell regeneration and glucose uptake. Chin J Nat Med 2025;23:492-503

4. Wang LK, Kong CC, Yu TY, Sun HS, Yang L, Sun Y, Li MY*, Wang W*: Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-induced beta-cell dedifferentiation. World J Diabetes 2025;16:95431

5. Li Z, Wu X, Kang Q, Ren Q, Zhang Y, Zhang Y, Jin Q, Wong FS*, Li M*: Alpha cells transdifferentiate into delta cells during the progression of autoimmunity in nondiabetic NOD mice. Am J Physiol Endocrinol Metab 2025;329:E692-E706

6. Jia J, Li Z, Zhao L*, Li M*: Glucagon receptor antagonism requires further mechanistic attention on alpha-cell physiology. Trends Endocrinol Metab 2025;

7. Jia J, Bai X, Kang Q, Jiang F, Wong FS, Jin Q*, Li M*: Blockade of glucagon receptor induces alpha-cell hypersecretion by hyperaminoacidemia in mice. Nat Commun 2025;16:2473

8. Yu ZW, Cai BP, Xie SZ, Zhang Y, Wang WH, Liu SZ, Bin YL, Chen Q, Fang MJ, Qi R, Li MY*, Qiu YK*: Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others. Nat Prod Bioprospect 2024;14:23

9. Xiang P, Bai X, Xing B, Li J, Zhang C*, Li M*: Full-length transcriptome annotation of a pyrosome, Pyrosoma atlanticum (Chordata, Thaliacea). Sci Data 2024;11:1433

10. Wu Y, Ma F, Yu L, Lin R, Lin S, Guo Z, Zhou M, Li M, Zhang Y, Xie J*: Unique Advantages of Dendrimers-Structured Mesoporous Silica Nanoparticles over Traditional Hollow Ones in Delivering Bcl2-Functional Converting Peptide for Multidrug Resistant Cancer Treatment. Adv Healthc Mater 2024:e2400888

11. Wang Z, Yu ZW, Zhang Y, Wang WH, Wu XY, Liu SZ, Bin YL, Cai BP, Huang SY, Fang MJ, Qi R, Li MY*, Qiu YK*: Hinokione: an abietene diterpene with pancreatic beta cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara. J Nat Med 2024;

12. Kang Q, Jia J, Dean ED, Yuan H, Dai C, Li Z, Jiang F, Zhang XK, Powers AC, Chen W*, Li M*: ErbB3 is required for hyperaminoacidemia-induced pancreatic alpha cell hyperplasia. J Biol Chem 2024;300:107499

13. Chen S, Peng H, Zhuang H, Wang J, Yan P, Zhang W, Zheng W, Li M, Wu X*: Optimized strategy to improve the outcomes of acute type A aortic dissection with malperfusion syndrome. J Thorac Cardiovasc Surg 2024;

14. Yuan H, Kang Q, Li Z, Bai X, Jia J, Han D, Wu X*, Li M*: Crispr-Cas9 mediated complete deletion of glucagon receptor in mice display hyperglucagonemia and alpha-cell hyperplasia. Biochem Biophys Res Commun 2023;643:121-128

15. Lu X, Yang B, Qi R, Xie Q, Li T, Yang J, Tong T, Niu K, Li M, Pan W, Zhang Y, Shi D, Li S, Dai C, Shen C, Wang X*, Wang Y*, Song J*: Targeting WWP1 ameliorates cardiac ischemic injury by suppressing KLF15-ubiquitination mediated myocardial inflammation. Theranostics 2023;13:417-437

16. Li Y, Liu C, Bai X, Li M, Duan C*: FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium. FEBS Lett 2023;597:1868-1879

17. Kuang Z, Guo K, Cao Y, Jiang M, Wang C, Wu Q, Hu G, Ao M, Huang M, Qin J, Zhao T, Lu S, Sun C, Li M, Wu T*, Liu W*, Fang M*: The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma. Br J Cancer 2023;129:1915-1929

18. Gao S, Lin X, Shi Y, Zhou H, Zheng X, Li M*, Lin T*: A New Hypoglycemic Prenylated Indole Alkaloid N-Oxide from Endophytic Fungus Pallidocercospora crystalline. Int J Mol Sci 2023;24

18. Gao S, Lin X, Shi Y, Zhou H, Zheng X, Li M*, Lin T*: A New Hypoglycemic Prenylated Indole Alkaloid N-Oxide from Endophytic Fungus Pallidocercospora crystalline. Int J Mol Sci 2023;24

20. Yu G, Sun P, Aierken R, Sun C, Zhang Z, Che Q, Zhang G, Zhu T, Gu Q, Li M*, Li D*: Linear polyketides produced by co-culture of Penicillium crustosum and Penicillium fellutanum. Marine Life Science & Technology 2022;4:237-244

21. Xu Y, Tian J, Kang Q, Yuan H, Liu C, Li Z, Liu J*, Li M*: Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish. Front Endocrinol (Lausanne) 2022;13:864631

22. Wang W, Shi Y, Liu Y, Zhang Y, Wu J, Zhang G, Che Q, Zhu T, Li M*, Li D*: Brasilterpenes A-E, Bergamotane Sesquiterpenoid Derivatives with Hypoglycemic Activity from the Deep Sea-Derived Fungus Paraconiothyrium brasiliense HDN15-135. Mar Drugs 2022;20

23. Wang Q, Tu X, Wang X, Cai Q, Yu L, Zhang X, Yi J, Wu Y, Xie G, Yuan H, Li M, Zhang X, Zeng Z*, Su Y*: Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXRalpha-targeted anti-mitotic agents. Bioorg Chem 2022;128:106069

24. Wang M, Wang X, Jiang B, Zhai Y, Zheng J, Yang L, Tai X, Li Y, Fu S, Xu J, Lei X, Kuang Z, Zhang C, Bai X, Li M, Zan T, Qu S, Li Q, Zhang C*: Identification of MRAP protein family as broad-spectrum GPCR modulators. Clin Transl Med 2022;12:e1091

25. Tie C, Zhu C, Jin Y, Liang H, Li M, Tian J, Wu C*: Instantaneous Phosphatidylcholine spatial specific regulation induced by formononetin revealed by DESI-MSI. International Journal of Mass Spectrometry 2022;471:116759

26. Qin J, Chen X, Liu W, Chen J, Liu W, Xia Y, Li Z, Li M, Wang S, Yuan Q, Qiu Y*, Wu Z*, Fang M*: Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agents targeting Nur77. Eur J Med Chem 2022;244:114849

27. Liu SZ, Xu GX, He FM, Zhang WB, Wu Z, Li MY, Tang XX*, Qiu YK*: New Sorbicillinoids with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus Hypocrea jecorina H8. Mar Drugs 2022;20

28. Kang Q, Zheng J, Jia J, Xu Y, Bai X, Chen X, Zhang XK, Wong FS, Zhang C*, Li M*: Disruption of the glucagon receptor increases glucagon expression beyond alpha-cell hyperplasia in zebrafish. J Biol Chem 2022:102665

29. Jia J, Kang Q, Liu S, Song Y, Wong FS, Qiu Y*, Li M*: Artemether and aspterric acid induce pancreatic alpha cells to transdifferentiate into beta cells in zebrafish. Br J Pharmacol 2022;179:1962-1977

30. Ding Y, Tao C, Chen Q, Chen L, Hu X, Li M, Wang S*, Jiang F*: Cynarin inhibits PDGF-BB-induced proliferation and activation in hepatic stellate cells through PPARγ. Open Chemistry 2022;20:1121-1129

31. Chen Y, Jia J, Zhao Q, Zhang Y, Huang B, Wang L, Tian J, Huang C, Li M*, Li X*: Novel Loss-of-Function Variant in HNF1a Induces beta-Cell Dysfunction through Endoplasmic Reticulum Stress. Int J Mol Sci 2022;23

32. Xu W, Zhou M, Guo Z, Lin S, Li M, Kang Q, Xu Y, Zhang X, Xie J*: Impact of macroporous silica nanoparticles at sub-50nm on bio-behaviors and biosafety in drug-resistant cancer models. Colloids Surf B Biointerfaces 2021;206:111912

33. Wang L, Shi Y, Che Q, Zhu T, Zhang G, Zhang X, Li M*, Li D*: Penipyrols C-G and methyl-penipyrol A, alpha-pyrone polyketides from the mangrove derived fungus Penicillium sp. HDN-11-131. Bioorg Chem 2021;113:104975

34. Li M*, Rong X, Lu L, Li Y, Yao K, Ge W, Duan C*: IGF-2 mRNA binding protein 2 regulates primordial germ cell development in zebrafish. General and Comparative Endocrinology 2021:113875

35. Bai X, Jia J, Kang Q, Fu Y, Zhou Y, Zhong Y*, Zhang C*, Li M*: Integrated Metabolomics and Lipidomics Analysis Reveal Remodeling of Lipid Metabolism and Amino Acid Metabolism in Glucagon Receptor-Deficient Zebrafish. Front Cell Dev Biol 2021;8:605979

36. Zhao L, Wang L, Aierken R, Wang W, Wang X*, Li M*: Characterization of Insulin and Glucagon Genes and Their Producing Endocrine Cells From Pygmy Sperm Whale (Kogia breviceps). Front Endocrinol (Lausanne) 2020;11:174

37. Wu Y, Ge P, Xu W, Li M, Kang Q, Zhang X, Xie J*: Cancer-targeted and intracellular delivery of Bcl-2-converting peptide with functional macroporous silica nanoparticles for biosafe treatment. Mater Sci Eng C Mater Biol Appl 2020;108:110386

38. Liu SZ, Tang XX, He FM, Jia JX, Hu H, Xie BY, Li MY*, Qiu YK*: Two new compounds from a mangrove sediment-derived fungus Penicillium polonicum H175. Nat Prod Res 2020:1-9

39. Kang Q, Hu M, Jia J, Bai X, Liu C, Wu Z, Chen W, Li M*: Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network. Int J Mol Sci 2020;21

40. Ge P, Niu B, Wu Y, Xu W, Li M, Sun H, Zhou H, Zhang X, Xie J*: Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety. Chemical Engineering Journal 2020;383:123228

41. Gan Q, Lin C, Lu C, Chang Y, Che Q, Zhang G, Zhu T, Gu Q, Wu Z, Li M*, Li D*: Staprexanthones, Xanthone-Type Stimulators of Pancreatic beta-Cell Proliferation from a Mangrove Endophytic Fungus. J Nat Prod 2020;83:2996-3003

42. Chen Z, Zhang D, Yan S, Hu C, Huang Z, Li Z, Peng S, Li X, Zhu Y, Yu H, Lian B, Kang Q, Li M, Zeng Z, Zhang XK*, Su Y*: SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem 2019;177:171-187

43. Liu J*, Wang GH, Duan YH, Dai Y, Bao Y, Hu M, Zhou YQ, Li M, Jiang F, Zhou H, Yao XS, Zhang XK: Modulation of the Nur77-Bcl-2 apoptotic pathway by p38alpha MAPK. Oncotarget 2017;8:69731-69745

44. Guzman CB, Zhang XM, Liu R, Regev A, Shankar S, Garhyan P, Pillai SG, Kazda C, Chalasani N, Hardy TA: Treatment with LY2409021, a glucagon receptor antagonist, increases liver fat in patients with type 2 diabetes. Diabetes, obesity & metabolism 2017;19:1521-1528

45. Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A, Sedgeman LR, Bozadjieva N, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich MC, Aamodt KI, Phillips N, Yan H, Bernal-Mizrachi E, Corbin JD, Vickers KC, Levy SE, Dai C, Newgard C, Gu W, Stein R, Chen W, Powers AC*: Interrupted Glucagon Signaling Reveals Hepatic alpha Cell Axis and Role for L-Glutamine in alpha Cell Proliferation. Cell Metab 2017;25:1362-1373 e1365

46. Li M, Zhao L, Page-McCaw PS*, Chen W*: Zebrafish Genome Engineering Using the CRISPR-Cas9 System. Trends Genet 2016;32:815-827

47. Li M, Page-McCaw P*, Chen W*: FGF1 Mediates Overnutrition-Induced Compensatory beta-Cell Differentiation. Diabetes 2016;65:96-109

48. Yin L, Maddison LA, Li M, Kara N, LaFave MC, Varshney GK, Burgess SM, Patton JG, Chen W*: Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs. Genetics 2015;200:431-441

49. Varshney GK, Pei W, LaFave MC, Idol J, Xu L, Gallardo V, Carrington B, Bishop K, Jones M, Li M, Harper U, Huang SC, Prakash A, Chen W, Sood R, Ledin J, Burgess SM: High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome Res 2015;25:1030-1042

50. Li M, Dean ED, Zhao L, Nicholson WE, Powers AC, Chen W: Glucagon receptor inactivation leads to alpha-cell hyperplasia in zebrafish. J Endocrinol 2015;227:93-103

51. Ao J, Mu Y, Xiang LX, Fan D, Feng M, Zhang S, Shi Q, Zhu LY, Li T, Ding Y, Nie L, Li Q, Dong WR, Jiang L, Sun B, Zhang X, Li M, Zhang HQ, Xie S, Zhu Y, Jiang X, Wang X, Mu P, Chen W, Yue Z, Wang Z, Wang J*, Shao JZ*, Chen X*: Genome sequencing of the perciform fish Larimichthys crocea provides insights into molecular and genetic mechanisms of stress adaptation. PLoS Genet 2015;11:e1005118

52. Mu Y, Li M, Ding F, Ding Y, Ao J, Hu S*, Chen X*: De novo characterization of the spleen transcriptome of the large yellow croaker (Pseudosciaena crocea) and analysis of the immune relevant genes and pathways involved in the antiviral response. PLoS One 2014;9:e97471

53. Maddison LA, Li M, Chen W*: Conditional gene-trap mutagenesis in zebrafish. Methods Mol Biol 2014;1101:393-411

54. Li M, Maddison LA, Page-McCaw P*, Chen W*: Overnutrition induces beta-cell differentiation through prolonged activation of beta-cells in zebrafish larvae. Am J Physiol Endocrinol Metab 2014;306:E799-807

55. Li M, Li Q, Yang Z, Hu G, Li T, Chen X*, Ao J*: Identification of cathepsin B from large yellow croaker (Pseudosciaena crocea) and its role in the processing of MHC class II-associated invariant chain. Dev Comp Immunol 2014;45:313-320

56. Li M, Maddison LA, Crees Z, Chen W*: Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional beta-cell number through enhanced self-replication in zebrafish. Zebrafish 2013;10:170-176

57. Xiao X, Li M, Wang K, Qin Q, Chen X*: Characterization of large yellow croaker (Pseudosciaena crocea) beta-actin promoter supports beta-actin gene as an internal control for gene expression modulation and its potential application in transgenic studies in fish. Fish Shellfish Immunol 2011;30:1072-1079

58. Li M, Ding Y, Mu Y, Ao J, Chen X*: Molecular cloning and characterization of caspase-3 in large yellow croaker (Pseudosciaena crocea). Fish Shellfish Immunol 2011;30:910-916

59. Zhao L, Mi T*, Zhen Y, Li M, He S, Sun J, Yu Z: Cloning of proliferating cell nuclear antigen gene from the dinoflagellate Prorocentrum donghaiense and monitoring its expression profiles by real-time RT-PCR. Hydrobiologia 2009;627:19-30

60. Wang X, Lu L, Li Y, Li M, Chen C, Feng Q, Zhang C, Duan C*: Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish. Am J Physiol Regul Integr Comp Physiol 2009;296:R1348-1357

61. Li M, Li Y, Lu L, Wang X, Gong Q, Duan C*: Structural, gene expression, and functional analysis of the fugu (Takifugu rubripes) insulin-like growth factor binding protein-4 gene. Am J Physiol Regul Integr Comp Physiol 2009;296:R558-566

62. Fan T, Li M, Wang J, Yang L, Cong R*: Purification and characterization of phenoloxidase from Octopus ocellatus. Acta Biochim Biophys Sin (Shanghai) 2009;41:865-872